The third movie in the Nerds series: The nerds are now in control of the university, as a result of Lewis Skolnick and the rest's actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won't reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.

The water guns Booger and the girls use while staying at the Skolnick house are Laramie's Super Soakers. Booger uses the 50 model (lime green), while the girls use the 100 model (large and blue) and the 30 model (small and orange.)

Tina:
Oh, I've seen you in the newspaper. You're the dean with the low I.Q.!

Errors made by characters (possibly deliberate errors by the filmmakers): When talking to Stan, Lewis introduces himself as "Class of 1981." This is impossible, as Lewis was still attending Adams in 1987 (when the second film took place.)