New York advertising executive Roger Thornhill is kidnapped by a gang of spies led by Philip Vandamm, who believe Thornhill is CIA agent George Kaplan. Thornhill escapes, but must find Kaplan in order to clear himself of a murder it is believed he committed. Following Kaplan to Chicago as a fugitive from justice, Thornhill is helped by beautiful Eve Kendall. In Chicago, she delivers a message to Kaplan that almost costs Thornhill his life when he is chased across a cornfield by a crop-dusting plane.

James Stewart was very interested in starring in this movie, begging Alfred Hitchcock to let him play Thornhill. Hitchcock claimed that Vertigo (1958)'s lack of financial success was because Stewart "looked too old". MGM wanted Gregory Peck, but Hitchcock instead cast Cary Grant, who, ironically, was actually 4 years Stewart's senior.

Eve Kendall:
What happened with your first two marriages?


Roger Thornhill:
My wives divorced me.


Eve Kendall:
Why?


Roger Thornhill:
They said I led a dull life.

Revealing mistakes: In the Chicago P.D. patrol car after Thornhill's arrest at the auction house, the cop on Thornhill's right forgets to lean as they simulate a turn. Cary Grant can be seen giving the errant actor a poke in the arm.

(1948) (uncredited)
Music by Jimmy McHugh
Lyrics by Harold Adamson
Played as background music at the Plaza Hotel