Former Vancouver City Coroner, Dominic Da Vinci, has just been elected Mayor of Vancouver. Opinionated, Mayor Da Vinci tries to implement some controversial policies for the City, including a red light district for prostitutes, safe injection sites for the troubled drug dependent population in the Downtown Eastside, and cross-training between the police department and fire & rescue. With the assistance of his hard working aides, Rita Mah and Sam Berger, Da Vinci is not averse to bending the rules or making back room deals to achieve his goals. But he must also work in holding together his caucus of City Councillors, and dealing with an uncooperative Police Chief who is at political and philosophical odds with the Mayor.

As in the previous series "Da Vinci's Inquest" the character of Dominic Da Vinci was based on the real-life B.C. Chief Coroner Larry Campbell, who after his tenure of coroner acted as a technical adviser on the show. Like the character of Dominic Da Vinci, Larry Campbell was elected mayor of Vancouver in 2002.