This teenage sitcom is named after its main character, likable but sissy schoolgirl Blossom Russo. It centers around her life at school and at home, where she lives with her single father, charming musician Nick Russo, who tries hard to be an exemplary parent, and her two elder brothers, the cool Anthony, the eldest, and sweet but rather weak and naive Joey. Her best friend, Six LeMeure, who is educationally neglected at her home and thus is almost always around at the Russos as well as at school, is the voice of mischief and thus often her partner in crime.
In the pilot, the younger of Blossom's elder brothers was called Donnie. In the series he was renamed Joey. The role was played by Joseph Lawrence in both titles.