Danny Williams, a successful nightclub singer, encounters a variety of difficult or amusing situations in trying to balance his career with his family; his outspoken wife Cathy, teenage daughter Teri from his first marriage, children Russ and Linda, and old-fashioned Uncle Tonouse. Later episodes feature Annette Funicello as an au pair girl. Most episodes conclude with a song by Danny or one of the children. Affection expressed as hostility ("I love you, you little jerk") and ironic humor characterize this show.

One of the episodes has Danny traveling through the town of Mayberry and introduces Andy Griffith as Sheriff Andy Taylor: "Make Room for Daddy: Danny Meets Andy Griffith (#7.20)" (1960). It was then spun off to the series "The Andy Griffith Show" (1960)