"Two Stupid Dogs" follows the lives of two dogs: the overly excited Little Dog (the dachshund) and easy-paced Big Dog (the sheepdog). These crazy canines don't know how to fit in the world, and they definitely don't have any know-how. They often find themselves in commonplace situations (going to the drive-in, walking through the mall, working on the farm), some not so common situations (stuck on a space shuttle, a contestant on a game show, getting mistaken for the prime minister) and even in some familiar situations (little red riding hood, Noah's ark, and Hanzel and Gretel). But no matter the situation, their stupidity usually leads them to calamitous results.

Each episode of this show featured two "2 Stupid Dogs" shorts and one "Super Secret Secret Squirrel" short (based on "The Secret Squirrel Show" (1965)).

Little Dog:
Hey, hey, why'd you wake me up?


Big Dog:
So we can wake up.


Little Dog:
If you didn't wake me up, I might've had a nightmare and it would've woke me up. Then, I could've woke you up and we would both be awake. But since you did wake me up, I can't wake up from this nightmare so i can't wake you up! So we're both still asleep.


Big Dog:
...What?