Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.

The Warner siblings are based in a roundabout way on senior producer Tom Ruegger's three real-life children. Originally, they were going to be ducks named Yakki, Smakki and Wakki, but this idea was canned (it was thought to be too similar to "DuckTales" (1987)), and the three were changed into platypi, then into Bosko-like inkblots. Along the way, they gained a female friend; finally, Yakki became Yakko, Smakki and Wakki were combined into Wakko, and the female friend was named Dot and made their sister.

Wakko:
Why does Mr. Plotz want to see me?


Dr. Scratchensniff:
Because you ate his conference table, Wakko.


Wakko:
But I was HUNGRY.